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A study published in Neurology has found that as problems not traditionally associated with brain health pile up, a person's chance of developing dementia increases.

As we age, those minor physical ailments – including sore feet, poorly fitting dentures and skin irritations – may turn out to be not so minor after all.

The 10-year study included more than 7,200 cognitively healthy 65-year-old Canadians who were asked questions about their health. The questions included known risk factors for Alzheimer's, such as high blood pressure and diabetes, they included 19 problems that seemingly have no connection with brain health – including vision and hearing, loose dentures, sinus congestion, arthritis, morning cough, and problems with the skin, stomach, kidneys or bowel.

Any healthy 65-year-old has an 18% chance of developing dementia in 10 years from aging, the study found that each health problem not traditionally associated with Alzheimer's increased that risk by 3.2%. The risk accelerated as more and more conditions were added, jumping to 40% among those in the study who reported as many as 12 conditions. Since age is a major risk factor for Alzheimer's, the study is in a sense identifying people who "age badly" - their biological age exceeds their chronological age.

Taking care of minor ailments improves a person's quality of life, no one has yet proved that fixing each problem would necessarily reduce the risk for Alzheimer's.

Walking as little as 30 minutes a day, three days a week decreases risk factors for dementia and improves overall health.

Original article AARP

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Dr. Potter, chief of the Division of Geriatrics and Gerontology at the University of Nebraska Medical Center says:

Stay mentally active. What actually happens is that as we get older, synapses in the brain are stimulated by mental activity, so this helps to preserve mental ability. Just being well-educated is a good idea. Education and mental stimulation helps to create and preserve and develop new connections. So taking a course later in life is a good idea.

Following a good heart-healthy diet is good for memory because what's good for your heart is good for your brain. And you can actually stimulate develop of new brain cells with physical activity.

Dr. Mastrianni, Associate Professor of Neurology; Co-Director, Center for Comprehensive Care and Research on Memory Disorders at the University of Chicago Medical Center says:

There things one can do to avoid developing Alzheimer's disease or memory decline associated with aging.  Lifestyle changes that have shown benefit include routine physical exercise, staying socially active and eating a heart-healthy diet. At least 30 minutes a day of physical activity gets your heart pumping and improves oxygenation of brain cells.

Social activity may include staying actively working, or volunteering in local organizations or clubs.  Research suggests that having a large network of social interactions helps to maintain good brain function and even delay Alzheimer's disease.

Finally, eliminating unhealthy practices such as cigarettes, too little sleep, and too much stress can't hurt and are likely to help your brain function better.

Dr. Shulman, assistant professor of neurology and associate director of Cognitive and Behavioral Neurology at the Pearl Barlow Center for Memory Evaluation and Treatment at the Silberstein Alzheimer's Institute at NYU Langone Medical Center says:

There are four main pillars of keeping healthy memory or maintaining brain fitness: healthy diet, exercise, keeping mentally stimulated and avoiding depression. There is no single entity that we can modify that will decrease the likelihood of someone developing Alzheimer's. It's a combination of applying all of these.

The issue with avoiding depression is a controversial one: Is depression itself a risk factor for dementia, or is the early sign of depression the earliest sign of dementia itself? It looks increasingly like it's a risk factor for Alzheimer's disease, and there's a whole host of complicated reasons, but it does seem that if you keep stress-free and depression-free, that in and of itself is insurance for healthy aging.

Original article My Health News Daily

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One day your doctor might give you this prescription to prevent Alzheimer’s: Eat less red meat and sugar; eat more fruits, vegetables, fish and olive oil.

At least that seems to be the finding of a new study that found that eating a diet low in saturated fat and sugary treats can improve your memory and may reduce your risk of developing dementia.

Researchers with the University of Washington and Veterans Affairs Puget Sound medical center decided to see if a change in diet could affect the risk for Alzheimer’s or benefit those already suffering some mild but early symptoms of the disease.

What they found was that a diet rich in fruits, vegetables, grains, fish and olive oil can improve some memory skills in both healthy older adults, as well as those already experiencing cognitive difficulty.

More importantly, eating this kind of diet can help healthy adults reduce their risk of developing dementia, says study researcher Suzanne Craft with the Memory Wellness Program at the VA.

Researchers found that after four weeks on the low-fat diet, subjects had fewer toxic proteins and evidence of inflammation in their spinal fluid, both considered to be bio-markers for Alzheimer’s, Craft said.

“I like to think of this kind of diet as promoting healthy brain aging, as well as reducing the risk of Alzheimer’s,” she said.

The Washington state researchers wrote that they decided to take a “whole-diet” approach, rather than focus on a single dietary component, such as omega-3 fish oil. They also chose to test the subjects’ spinal fluid for bio-markers because of the importance of the central nervous system to brain health.

The 49 subjects, all older than 60, included 20 healthy adults with no signs of memory decline, and 29 who were at high-risk for Alzheimer’s, having already been diagnosed with some cognitive impairment.

They were randomly selected to either follow a four-week low-saturated fat, high-fiber plan similar to a Mediterranean diet, or a four-week high-saturated fat diet that included foods like red meat, butter, french fries and soda.

Both groups ate the same amount of protein and the diets were balanced so subjects did not lose or gain or weight.

However, for those who want to protect their brain health, it seems pretty clear from these preliminary results that eating a healthy diet is a powerful first step.

Original article on AARP

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Though a cure for Alzheimer's disease remains elusive, experts believe earlier and more accurate diagnosis will aid efforts to discover effective therapies. Marilyn Albert, Ph.D., director of the Johns Hopkins Alzheimer’s Disease Research Center, answers the question: "Why is early diagnosis of Alzheimer's disease important if no treatments currently exist to delay progression of the disease?" 

Early and more accurate diagnosis of Alzheimer’s disease is important in helping us develop a better understanding of the biology of the disease. This, in turn, will help researchers design and test new drugs that will intervene earlier in the disease process. 

We use the term Alzheimer's disease to talk about people who are demented, but there are many people with it who aren't yet demented. In fact, one third of all older adults show Alzheimer’s disease pathology in their brains, though they may not yet show symptoms. 

We know that the symptoms of Alzheimer’s disease progress gradually over many years. People with Alzheimer’s disease don’t go from normal to demented overnight. Instead, the disease is a continuum, and earlier diagnostic procedures will help us treat it as such. 

For instance, we understand that high blood pressure is a risk factor for stroke. So, when we go to the doctor and find out that we have high blood pressure, we start to treat it right away, years before a stroke might occur. The same should apply to Alzheimer’s disease. 

We want to identify those who are at risk years before dementia occurs, because we are working hard toward the day when we can diagnose and treat those risk factors for Alzheimer’s disease in the earliest stages -- just as we might treat high blood pressure or cholesterol.

From Johns Hopkins Health Alert

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The link to healthy diets and brain health is well established. The link to diet and Alzheimer's disease is less clearly established, but new information on curcumin (found in turmeric) may prove to be helpful.

The brain is particularly vulnerable to oxidative damage due to its high rate of metabolism and long-lived neurons. Free radicals can cause oxidative damage to important cellular components such as DNA, or the cell membrane. Cells may function poorly or die if there is too much oxidative damage.

Antioxidants defend the cells from free radical damage. Many long term studies have demonstrated that those with higher antioxidants in their diets from fruits, vegetables and certain spices have slower rates of cognitive decline than those who ate less of these foods.

Curcumin has been studied recently because of the low rates of Alzheimer's disease in India. The Indian population consumes large amounts of curcumin through Tumeric and have a relatively low (4 times less) incidence of Alzheimer's disease compared to the U.S. population.

Curcumin is a member of the ginger family and is the main ingredient of turmeric, a spice used in curry and many Middle Eastern dishes. Curcumin is an antioxidant with nonsteroidal anti-inflammatory properties which prevents the damage caused by free radicals. The more antioxidants in the diet, the more the cells are protected.

The National Institutes of Health and other research organizations have been completing Alzheimer's clinical trials. Recently, curcumin has been in the forefront of much of this research. Curcumin's powerful anti-inflammatory and anti-oxidant properties suppress the buildup of beta-amyloid in brain tissue.

The National Institute of Neurological Disorders and Stroke (NINDS) studied mice and found that curcumin crosses the blood-brain barrier to bind with beta-amyloid peptides. These peptides are dangerous when they build up into plaques.

As Alzheimer's disease develops, neurons go through a process from a healthy state to some loss of molecular efficiency, to a loss of synaptic function, to loss of synapses, and, ultimately, to cell death. When curcumin was fed to aged mice, there was a reduction in amyloid levels and the overall amount of dangerous plaque.

More studies are needed to investigate the safety and tolerability of curcumin in the elderly population. Research is also needed in the areas of using curcumin to prevent Alzheimer's Disease as well as to lessen symptoms.

As clinical trials produce more information about the efficacy of curcumin, guidelines will be established for those at risk and for those affected.

Original article on CDApress.com by Seanne Safail, , Ph.D, RD

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Disease develops years before symptoms show.

New guidelines for diagnosing Alzheimer's disease set forth methods for identifying the disease before it progresses to full-blown dementia, and for the first time include lab and brain-imaging tests that can help identify Alzheimer's as the likely cause of a person's mental decline.

The guidelines, revised for the first time in 27 years, reflect a firm consensus among Alzheimer's researchers that the disease begins to attack the intricate structures of the brain 10 years or more before the disabling mental problems appear. Therefore, to be effective, drug or other therapies will have to begin work early in that process.

So far, though, there are no therapies that alter the course of Alzheimer's disease. And in a media briefing, authors of the new diagnosis guidelines emphasized that while testing for Alzheimer's pathology in the brain may one day be used to identify the disease at much earlier stages, today the tests are primarily a research tool. They are not ready for routine use in doctors' offices.

Delaying disability

Even so, doctors hope the new diagnostic criteria encourage people with worrisome memory problems to seek help. There's a lot patients and their families can do to minimize the impact of Alzheimer's, from structuring the patient's environment to optimizing medical care, activities, exercise and diet.

New tests outlined in the guidelines involve looking at the brain with imaging technologies and examining the fluid obtained by a spinal tap. The imaging studies can reveal so-called plaques made up of a protein called amyloid, a defining feature of Alzheimer's. They also can indicate characteristic patterns of shrinkage or reduced metabolic activity in the brain. The cerebrospinal fluid tests look for levels of amyloid as well as of another protein, tau, which makes up the twisted strands or "tangles" that, like plaques, are signature brain pathology in Alzheimer's.

Weaknesses of the tests

Research studies have demonstrated that all these tests can help identify Alzheimer's as the cause of a patient's dementia, and can help predict which patients with milder symptoms will go on to develop dementia. But the tests aren't conclusive in themselves. They aren't standardized so that a certain result means the same thing in every medical center. And there's no clear cutoff separating normal findings from those indicating a problem.

Original article by: Katharine Greider from AARP Bulletin

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Brain scans may help identify which individuals with a mild decline in their mental abilities will go on to develop Alzheimer's disease, according to a new study.
 
The research focused on patients with mild cognitive impairment, a condition in which people experience noticeable declines in their cognitive function, including memory and language problems. These changes are not severe enough to interfere with everyday activities, according to the Alzheimer's Association.
It is known that about 15 to 20 percent of such patients will go on to develop Alzheimer's, but researchers don't know which ones.

In the new study, which involved magnetic resonance imaging (MRI), researchers were able to identify a high-risk group – patients who had a 69 percent chance of developing Alzheimer's disease in the next year.

The study used the MRI scans to identify brain characteristics that put people at risk for Alzheimer's. The researchers determined some patients had just a 3 percent risk of developing Alzheimer's in the next year, which is about the same as for a healthy older person. Others had a 40 percent risk of developing the condition in the next year, or double the risk associated with a diagnosis of mild cognitive impairment, and still others were identified as part of the high-risk group, said study researcher Linda K. McEvoy, an assistant professor in the department of radiology at the University of California, San Diego School of Medicine.

A similar technique could be used one day by doctors to determine the Alzheimer's risk for patients with mild cognitive impairment. However, the patients in the study were not representative of the general population — they had been selected to exclude people who experienced other types of memory problems, such as those due to a stroke. A larger study would be needed before the results could be translated to the doctor's office.

Alzheimer's disease risk
The study looked at MRI scans of the brains of 203 healthy adults, 164 patients with Alzheimer's disease and 317 patients with mild cognitive impairment. Each patient had their brain scanned at the start of the study and again a year later.

The researchers first compared the brains of Alzheimer's disease patients with those of healthy people, looking for differences in the degree of  shrinkage, or atrophy, in particular areas of the brain. Once they developed a way to distinguish these two groups of people, "we could use the same equations on the mild cognitive impairment (MCI) subjects to determine their risk of developing Alzheimer's disease," McEvoy said.
 
When the researchers included information about how the brains had changed in the time between the two scans, they were able to identify the high-risk group.

Future applications
Information in this study will be critical once we have ways to prevent Alzheimer's disease, McEvoy said. "Currently there's no cure or prevention for Alzheimer's disease. But there's a lot of research going on right now into different potential therapies. If any of those therapies turn out to be useful, then this kind of information will be crucial — a doctor needs to know who's at higher risk in order to treat them".

 Original article by Rachael Rettner- MyHealthNewsDaily

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As we get older, many of us will notice changes in our memory. Forgetfulness is a normal part of getting older, however, dementia and Alzheimer's disease is not. How can we tell the difference? We all worry, about ourselves and our parents as we watch them age; and with good reason.

Presently, one in ten people 65 and older has Alzheimer's, about 5 million people. But only half have been diagnosed with the disease. It is estimated that by 2050 as many as 16 million people will have it.
As we become more and more educated about this terrible disease, we often find ourselves wondering when we or someone we love will get it, not if we or someone we love will get it. You may be concerned because you have noticed recurring "senior moments".  As we age, we notice our senior moments more and more.
 
So where does normal forgetfulness end and mild cognitive impairment begin? Some experts think that mild cognitive impairment (MCI) is the early signs of Alzheimer's disease. Unfortunately, there is no definitive test for diagnosing Alzheimer’s, but your personal history and mental status exams are accurate about 90% of the time. Alzheimer's progresses very slowly for most people. The downward slide of thinking, memory, and judgment are gradual, over the span of many years.

If you have concerns about yourself or a loved one, find out all you can about your own, or their, personal history and speak with your doctor. Education about Alzheimer’s Disease is the best way to understand an prepare yourself, if necessary, for this terrible disease.

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Alzheimer's disease symptoms result from physical changes in the brain. What causes these changes is still somewhat of a mystery, however researchers have a leading theory of how the Alzheimer's disease progresses.
 
In a healthy brain, certain chemical processes ensure the proper functioning of neurons. One is the processing of amyloid precursor protein (APP) that is attached to the outer membrane of nerve cells. Certain enzymes cut off a section of the protein; while another enzyme snips a second portion and releases APP from the cell’s membrane.

These APP fragments are then broken down and removed from the brain. Another process, which we won’t get into here, carries nutrients through the nerve cells to keep them functioning normally.
 
When the processes that keep a healthy brain functioning go awry, a different enzyme, cuts shorter APP fragments from the nerve cell membrane. These smaller pieces are more resistant to breakdown and tend to clump together in toxic clusters and eventually they collect into plaques that interfere with nerve cell functioning. Within neurons, the transport of nutrients is crippled and nerve cells are destroyed. Loose threads join together to form knotted strands inside neurons. These cause further neuron destruction.

In the early stages of Alzheimer’s, plaques and tangles form in brain areas responsible for learning, thinking, and planning -- in particular, the hippocampus. This is why forgetfulness, disorientation, and verbal repetition are often among the earliest signs of Alzheimer’s. As nerve cell destruction spreads more brain areas are affected, especially the cerebral cortex, responsible for language, reasoning, and judgment. Speaking skills become impaired and emotional outbursts grow more frequent.

When large areas of nerve cells die off in the advanced Alzheimer’s stage, brain sections atrophy and the whole brain shrinks to as much as three quarters of its original size. People with Alzheimer’s lose most of their ability to communicate, walk, and care for themselves.  

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Exercising and reducing stress are both very important to keep your brain functioning at its peak. A healthy brain not only helps improve memory, mental clarity and countless other cognitive tasks essential for better health and well-being, it may also reduce the risk of diseases such as Alzheimer’s. Since the nerve cells in our brains degrade as we age, there’s no better time than now to keep your brain active, so that it functions well for years to come. One of the most important things you can do to improve your brain health is learning something new.

Learn something new that you’re not familiar with is a very important task to keep up with throughout your life. Brain games, which are generally good for “exercising” your brain are important to learn and play as well, such as crosswords. But, there are many other things that can increase brain activity, such as learning how to play a new instrument or sport, picking up a new hobby, or learning a new language. The important thing is that it needs to be something unfamiliar. If you already play hearts try playing solitaire, or learn an entirely new game to master. Instrument learning is one of the best ways to train your brain, as it works your brain as lot more. By performing diverse tasks, you’re working out different parts of your brain. Contact us today to learn more about activities our assisted living communities have to offer or learn about Alzheimer's.

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