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Lewy body dementia is a form of dementia that may account for as many as 20% of all dementia cases. Lewy bodies are tiny spherical deposits of a protein called alpha-synuclein that are found in the brains of patients with this disorder. The presence of Lewy bodies throughout the brain disrupts the brain's normal functioning. Lewy body dementia is now believed to be the second most common specific cause of dementia after Alzheimer's disease.

There is considerable overlap between Lewy body dementia and Alzheimer's and Parkinson's disease. In Lewy body dementia, patients experience a loss of dopamine-producing nerve cells similar to that seen in Parkinson's disease. They also lose acetylcholine-producing nerve cells, similar to what occurs in Alzheimer's disease.

Patients with Lewy body dementia often experience cognitive problems associated with Alzheimer's disease, such as memory loss, spatial impairment and language difficulties. They may also develop parkinsonian symptoms, such as muscle rigidity, a blank facial expression, soft voice, tremor, poor balance and gait disturbances. Some patients initially diagnosed with Parkinson's disease later go on to develop a dementia that closely resembles Lewy body dementia.

Certain symptoms of Lewy body dementia help distinguish it however. For example, early in the illness Lewy body dementia patients often experience detailed and extremely vivid hallucinations, unlike people with Alzheimer's disease. People with Lewy body dementia also tend to show marked fluctuations in their cognitive functioning, often several times a day. In addition, they tend to fall asleep easily during the day and have restless, disturbed sleep with behavioral acting out.

Recognition of these symptoms leads to an accurate diagnosis of Lewy body dementia. A correct diagnosis is particularly important because the medical management of patients with Lewy body dementia presents special challenges. The drugs that are normally used can aggravate other problems and cause potentially serious adverse reactions. In particular, antipsychotic drugs can provoke dangerous side effects, including a return to psychosis, and must be used cautiously, if at all. In addition, levodopa, a drug normally used to treat parkinsonian symptoms, may worsen hallucinations, so its dosage needs to be carefully adjusted in patients with Lewy body dementia.

This disease is named for Frederick Lewy, the physician who first identified them in 1912 while working in the laboratory of Dr. Alois Alzheimer.

Original article from Johns Hopkins

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Carrying around extra pounds during middle age was associated with a higher risk of dementia later in life in a new study that followed twins in Sweden for 30 years.

The research was not set up to prove that dementia was caused by the added weight, but Dr. Weili Xu, the study's lead author, said that the evidence is pointing in that direction.

The findings suggest that "control of body fat as early as middle life is important to prevent dementia later in life," she told Reuters Health.

Xu and her colleagues analyzed data from close to 9,000 Swedish twins.

When the participants were an average age of 43, they gave researchers information about their height and weight.

Thirty years later, the researchers examined the same individuals for signs of declining thinking and memory skills, and then diagnosed some of them with Alzheimer's disease and other types of dementia.

Close to one in three of the participants were overweight or obese in middle age. And those that were had about an 80 percent higher chance of getting any kind of dementia than people of normal weight.

The more participants weighed in mid-life, the higher their chance of getting dementia or "questionable dementia" - meaning they had signs of thinking and reasoning problems, but not enough to be diagnosed with dementia.

In total, about 4 percent of everyone in the study was diagnosed with dementia, and another 1 to 2 percent with questionable dementia.

Despite the link between excess pounds in midlife and later dementia, when the researchers looked specifically at 137 twin pairs who were "discordant" - one twin had dementia and the other didn't - the tie to midlife overweight shrank considerably.

While Xu said that finding suggests that "there are some common genes that predispose (people) to both diseases (overweight and dementia)," it could also be that it was just more difficult to establish a solid link in such a small sample.

Whether genes predispose a person to being overweight in adulthood, or it's just bad eating habits, the likely explanation for the link to dementia is that fat tissue in the body releases hormones and other signaling cells that may affect the brain's functioning.

In addition, extra weight has been shown to increase a person's risk for diabetes and heart and blood vessel diseases - and those conditions are related to a higher dementia risk. However, the link between weight and dementia remained even after the researchers took other diseases into account.

The findings are the latest evidence that preventing Alzheimer's disease and dementia starts long before their signs and symptoms show up.

"People need to understand that what they do today could have an effect on them 30 or 40 years from now.”
When it comes to maintaining a healthy weight, what's good for the heart is good for the brain.

Original article - MSN

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