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What is the Difference Between Alzheimer’s and Lewy Bodies?

- Monday, January 05, 2015

Often a parent is originally diagnosed with Alzheimer’s, but then the diagnosis is changed to dementia with Lewy bodies. Many need the difference explained? And does this change his prognosis?

The Lewy Body Dementia Association has a terrific website that provides a complete range of information about this condition, man find it very helpful.

Some things to note at a quick glance are:

  • Memory loss tends to be a more prominent symptom in early Alzheimer’s than in early dementia with Lewy bodies (DLB), although advanced DLB may cause memory problems in addition to its more typical effects on judgment, planning and visual perception.
  • Movement symptoms are more likely to be an important cause of disability early in DLB than in Alzheimer’s, although Alzheimer’s can cause problems with walking, balance and getting around as it progresses to moderate and severe stages.
  • Hallucinations, delusions and misidentification of familiar people are significantly more frequent in early-stage DLB than in Alzheimer’s.
  • REM sleep disorder is more common in early DLB than in Alzheimer’s.
  • Disruption of the autonomic nervous system, causing a blood pressure drop on standing, dizziness, falls and urinary incontinence, is much more common in early DLB than in Alzheimer's.

Everyone is unique, but taking care of a loved one with Alzheimer’s or another form of dementia such as DLB can be incredibly demanding. You can’t do it alone, and you will need lots of support – from the medical team, with caregiving tasks and emotionally as you travel this caregiving journey. I encourage you to check out resources online, including webinars made specifically for caregivers like you, www.helpforalzheimersfamilies.com.

Understanding Lewy Body dementias

Lewy body dementias (LBD) affect an estimated 1.4 million individuals and their families in the United States. At the Lewy Body Dementia Association (LBDA), we understand that though many families are affected by this disease. Few individuals and medical professionals are aware of the symptoms, diagnostic criteria or even that LBD exists. There are important facts about Lewy body dementias you should know if you, a loved one or a patient you are treating may have LBD.

LBDs are the second most common form of degenerative dementia. The only other form of degenerative dementia that is more common than LBD is Alzheimer’s disease (AD). LBD is an umbrella term for dementia associated with the presence of Lewy bodies (abnormal deposits of a protein called alpha-syncline) in the brain.

 LBD can have three common presentations:

  • Some individuals will start out with a movement disorder leading to the diagnosis of Parkinson's disease and later develop dementia. This is diagnosed as Parkinson’s disease dementia.
  • Another group of individuals will start out with a cognitive/memory disorder that may be mistaken for AD, but over time two or more distinctive features become apparent leading to the diagnosis of ‘dementia with Lewy bodies’ (DLB).
  • Lastly, a small group will first present with neuropsychiatric symptoms, which can include hallucinations, behavioral problems, and difficulty with complex mental activities, also leading to an initial diagnosis of DLB.

Regardless of the initial symptom, over time all three presentations of LBD will develop very similar cognitive, physical, sleep and behavioral features.

The most common symptoms of LBD include:

  • Impaired thinking, such as loss of executive function (planning, processing information), memory, or the ability to understand visual information.
  • Fluctuations in cognition, attention or alertness.
  • Problems with movement including tremors, stiffness, slowness and difficulty walking.
  • Visual hallucinations (seeing things that are not present).
  • Sleep disorders, such as acting out one’s dreams while asleep.
  • Behavioral and mood symptoms, including depression, apathy, anxiety, agitation, delusions or paranoia.
  • Changes in autonomic body functions, such as blood pressure control, temperature regulation, and bladder and bowel function.

The symptoms of LBD are treatable. All medications prescribed for LBD are approved for a course of treatment for symptoms related to other diseases such as Alzheimer’s disease and Parkinson’s disease with dementia and offer symptomatic benefits for cognitive, movement and behavioral problems.

Early and accurate diagnosis of LBD is essential. Early and accurate diagnosis is important because LBD patients may react to certain medications differently than AD or PD patients. A variety of drugs, including anticholinergics and some antiparkinsonian medications, can worsen LBD symptoms.

Traditional antipsychotic medications may be contraindicated for individuals living with LBD. Many traditional antipsychotic medications (for example, haloperidol, thioridazine) are sometimes prescribed for individuals with Alzheimer’s disease and other forms of dementia to control behavioral symptoms. However, LBD affects an individual’s brain differently than other dementias. As a result, these medications can cause a severe worsening of movement and a potentially fatal condition known as neuroleptic malignant syndrome (NMS). NMS causes severe fever, muscle rigidity and breakdown that can lead to kidney failure.

Early recognition, diagnosis and treatment of LBD can improve the patients’ quality of life.

LBD may affect an individual’s cognitive abilities, motor functions, and/or ability to complete activities of daily living. Treatment should always be monitored by a physician and may include: prescriptive and other therapies, exercise, diet, sleep habits, changes in behavior and daily routines.

Individuals and families living with LBD should not have to face this disease alone. LBD affects every aspect of a person – their mood, the way they think, and the way they move. LBD patients and families will need considerable resources and assistance from healthcare professionals and agencies. The combination of cognitive, motor and behavioral symptoms creates a highly challenging set of demands for continuing care. LBDA was formed to help families address many of these challenges.

Physician education is urgently needed. An increasing number of general practitioners, neurologists, and other medical professionals are beginning to learn to recognize and differentiate the symptoms of LBD – the most misdiagnosed dementia – from other diseases. However, more education on the diagnosis and treatment of LBD is essential.

There is much research still needed. Research needs include tools for early diagnosis, such as screening questionnaires, biomarkers, neuroimaging techniques, and more effective therapies. With further research, LBD may ultimately be treated and prevented through early detection and neuroprotective interventions. Currently, there is no specific test to diagnose LBD.

Also, reach out to find a support group in your area. For more information on assisted living, conact Spring Arbor.

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